A new study analyzed the methylome of seven primary RMC tumors using 850 K methylation arrays and found that it is different from that of other SMARCB1-deficient malignancies such as malignant rhabdoid tumors and epithelioid sarcomas. This is consistent with the hypothesis that RMC has a different cell of origin and distinct biological profile than that of malignant rhabdoid tumors and epithelioid sarcomas.